Application of titanium in pharmaceutical industry

Pharmaceutical industry is an important industry related to people's physical and mental health, including pharmaceutical, medical machinery, sanitary materials and other fields, which occupies an important position in the national economy. Titanium is widely used in the pharmaceutical industry because it is non-toxic and harmless and has good compatibility with human body.

In pharmaceutical production, because the production of drugs is inseparable from acid, alkali and salt, pharmaceutical equipment is easy to be damaged by corrosion. The use of steel equipment can not only solve the problem of serious equipment corrosion, but also cause a lot of human, material and financial losses, affecting normal production. The use of titanium equipment solves this problem well.

In the production of several main commonly used drugs, the equipment made of titanium has good corrosion resistance and considerable economic benefits.

In China, vitamin B1 is mostly produced by hydrogen chloride conversion method. The finished product is dried by cyclone and separated by two cyclones. The medium is thiamine hydrochloride with pH value of 2.5 and temperature of 110 ℃, which is highly corrosive. The original drying device is made of stainless steel, and the inner wall is corroded and perforated after more than one year of use, which seriously pollutes the drugs.

After using titanium spiral feeder, cyclone separator, vortex body, hopper, discharge pipe and titanium lining of tail gas tank, the production qualification rate of vitamin B1 is increased from 95% to 100%, and the equipment has been used for more than 7 years without corrosion. The cost of titanium can be recovered in 3 months.

Vitamin C is made from sorbitol, fermented into sorbose by black vinegar bacteria, and then fermented by Pseudomonas to obtain low concentration gulonic acid, which is concentrated and transformed into finished product by hydrogen chloride.

Titanium is very corrosion resistant in high temperature gulonic acid. In the production process of this product, titanium tubular heat exchanger, titanium dhc-500 butterfly sedimentation automatic slag removal centrifuge and TC4 cast impeller are used. No corrosion has been found for many years.

The main raw material for the chemical synthesis of chloramphenicol (an antibiotic) is methyl dichloroacetate, which contains about 2% vinyl chloride and trichloroethylene. If steel equipment is used in the refining process, it is prone to serious corrosion, and it is intact after switching to titanium equipment.

Procaine hydrochloride used in local anesthesia is produced with p-nitrotoluene as raw material. It is highly corrosive in the whole production process of oxidation to p-nitrobenzoic acid, acetic acid washing and mother liquor recovery. Therefore, the production equipment adopts titanium steel composite plate inner cylinder, titanium bubble tube, glacial acetic acid circulating condenser and vapor-liquid separator, so as to solve the corrosion problem.

Qusujing (tetraimidazole) is a highly effective intestinal nematode repellent. Stainless steel equipment was originally used in the production of this product, which caused product pollution due to corrosion. After using titanium as feed pipe and pump inlet pipe, the corrosion problem was successfully solved.

Nitrochlorophenol is a specific veterinary drug for the treatment of Fasciola hepatica in cattle and sheep. It is produced with sulfuric acid, nitric acid, glacial acetic acid and chlorine containing solution. The titanium pin tank agitator has been operating normally so far. In addition, activated carbon is widely used for decolorization in pharmaceutical production. After changing the stainless steel suction filter to titanium suction filter, it is still intact after 9 years of use.